Arginine metabolic control of airway inflammation

l-Arginine administration attenuates airway inflammation by altering l-arginine metabolism in an NC/Nga mouse model of asthma

Changes in l-arginine metabolism, including increased arginase levels and decreased nitric oxide production, are involved in the pathophysiology of asthma. In this study, using an intranasal mite-induced NC/Nga mouse model of asthma, we examined whether administration of l-arginine ameliorated airway hyperresponsiveness and inflammation by altering l-arginine metabolism. Experimental asthma was...

Clinical control of asthma associates with measures of airway inflammation.

BACKGROUND Control of asthma is the goal of asthma management worldwide. The Global Initiative for Asthma defined control by a composite measure of clinical findings and future risk but without using markers of airway inflammation, the hallmark of asthma. We investigated whether clinical asthma control reflects eosinophilic inflammation in a broad population. METHODS Control of asthma was ass...

L-Arginine Metabolic Pathways

The present review will give an overview of the biochemistry and metabolism of L-arginine focusing on the mechanisms which may either provide or limit cellular availability of this amino acid for nitric oxide synthases and arginase / polyamine pathway and describe possible interactions between these pathways. In addition, emerging species differences in the expression and role of arginases are ...

Metabolic Control of Th17 Cell Generation and CNS Inflammation.

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), results from uncontrolled auto reactive T cells that infiltrate the CNS and attack the myelin sheath. Th17 cells play a prominent role in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Extensive studies have focused on understanding the roles of c...

Allergic Airway Inflammation